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KMID : 1098420090170040243
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 4 p.243 ~ p.250
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Antioxidant and Anti-fibrotic Properties of Root Extract of Lythrumsalicaria L. in CCL4-Induced Liver Fibrosis Rat Model
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Lee Seung-Eun
Han Hee-Sun
Seo Jin-Sook
Park Chung-Berm
Cha Sun-Woo
Park Ho-Ki
Seong Nak-Sul
Ahn Tae-Jin
Chung Hae-Young
Kim Young-Ock
Kim Geum-Soog
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Abstract
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Fifty percent ethanol extract of Lythrum salicaria Linne root (LSR) was tested in vitro on antioxidant activity, and furthermore was investigated on antioxidative and fibrosis protecting activities in -induced liver fibrosis rat model. Ratio of hepatic GSH/GSSG (reduced glutathione/oxidized glutathione) as bio-parameter of antioxidant level in plus LSR-treated rats for 6 weeks significantly increased from 2.8- to 5.7-fold than that of -treated rats at p < 0.05. Thiobarbituric acid reactive substances (TBARS) contents in plus LSR-treated rats ranged from 1.57- to 2.19-fold of normal rats and were lower than those in plus silymarin-treated rats (-fold of normal rats) (p < 0.05). Amounts of hydroxyproline of liver tissue showing the content of total collagen, a parameter of fibrosis, in plus LSR-administrated rat livers were /mg (, compared with that in -treated rat livers (/mg tissue), which were significantly lower than those in plus silymarin-administrated rats being /mg (). This collagen reducing effect of liver tissue in plus LSR-treated rats was supported by histological observation using microscopy assay. From the results, we conclude that the root of L. salicaria have efficient antioxidant potential and effective antifibrotic activities.
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KEYWORD
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Antioxidant, Antifibrotic, Collagen, Liver Fibrosis, ROS
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